Selected Publications
Graduate School Era
Complement factor H polymorphism and age-related macular degeneration
Published in Science in 2005
Role: Data Analyst
Genome-wide association with diabetes-related traits in the Framingham Heart Study
Role: Data Analyst
Mentor: Jose Florez
The genetic architecture of type 2 diabetes
From the GoT2D and T2D-GENES Consortia
The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants
Fadista J, Manning AK, Florez JC, Groop L.
Instructor Era
GEM: scalable and flexible gene-environment interaction analysis in millions of samples.
Role: Principal Investigator
Mentee: Kenneth Westerman
Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
Manning AK, Ngwa JS, Hendricks AE, Liu CT, Johnson AD, Dupuis J, Cupples LA
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population is Associated
Manning A, Highland H, Gasser J, Sim X, et al
A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus
Manning AK*, Goustin AS*, Kleinbrink EL*, Thepsuwan P, Cai J, Ju D, Leong A, Udler MS, Brown JB, Goodarzi MO, Rotter JI, Sladek R, Meigs JB, Lipovich L
A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets
The first of many papers reporting the results of the first round of genome-wide association studies in the Framingham Heart Study.
Role: Programmer, Database Administrator, Data Analyst
Mentors: Adrienne Cupples, James Meigs
Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits
My first “methods” paper, although I didn’t realize it at the time!
Meigs JB, Manning AK, Dupuis J, Liu C, Florez JC, Cupples LA
Role: Statistician, Data Analyst, Writer
Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients
Manning A, LaValley M, Liu C, Rice K, An P, Liu Y, Miljkovic I, Rasmussen-Torvik L, Harris T, Province M, Borecki I, Florez J, Meigs J, Cupples L, Dupuis J
Role: Statistician, Writer
Mentors: Adrienne Cupples, Josée Dupuis
Postdoctoral Research Era
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
Jun, G., Manning, A., Almeida
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Role: Data Analyst
Mentor: Adrienne Cupples
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
A paper from the MAGIC Consortium
Manning A, Hivert M, Scott R, et. al
Role: Data Analyst, Project Manager